Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief
Abstract The current opioid crisis urgently calls for developing non-addictive pain medications.Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action.Extracellular adenosine alleviates pain by activating the adenosine A1 receptor igora vibrance 6-12 (A1R).However, efforts to develop A1R agonists have face